CORETOX 100 Unit

4. Coretox 100 Units should only be mixed with sodium chloride solution. Do not mix with other types of solutions or products. If the product bubbles up or is strongly agitated, the product’s properties change or become denatured. Therefore, make sure to slowly introduce the sodium chloride solution.

5. After Coretox 100 Units is dissolved in the sodium chloride solution, it should be injected into the patient within 24 hours. If the mixture is not injected into the patient immediately, store in the refrigerator at 2 ~ 8ºC. Even if the mixture is stored in the refrigerator, it should still be injected into the patient within 24 hours. Also, write on the label the date and time when the product was dissolved. After dissolving, the product should be transparent, and should not contain any abnormal substances. If the product changes color or if foreign materials are detected, do not use this product and discard it immediately.

6. Coretox 100 Units does not contain any preservatives. It is not recommended to use 1 vial for more than 1 patient. After usage, the remaining product should be discarded.

7. Since each botulinum toxin product may be manufactured with a different toxin unit, the toxin unit of one product cannot be converted to the unit of another product.

How to administer Coretox 100 Units

To address glabellar lines (forehead wrinkles): Using a 30 gauge needle, inject the dissolved product into the corrugator muscles and the procerus muscle (a total of 5 areas). 0.1ml of the product should be injected in each area, with a total of 20 U being injected.

When injecting into the inner corrugator supercilii muscle and the medial eyebrows, inject at least 1 cm from the edge of the eye. During injection, the needle should be aimed at the upper center, and the injection volume should be accurate. Careful attention should be paid to NOT inject Coretox 100 Units into the blood vessel. To prevent Coretox 100 Units from being injected into the blood vessel(exudation) below the orbital ridge, place the thumb or index finger below the orbital ridge prior to injection. The corrugator muscle and the orbicularis oculi muscle move in the middle of the forehead to make glabellar folds on the face. The procerus muscle and the depressor supercilii muscle pull the forehead downward. These muscles create frown lines or wrinkles. Because the muscle position, muscle size, and use of muscle vary from person to person, the effective dose is determined by complete observation of the patient's ability to control the implanted surface muscles.

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‌To address wrinkles around the eyes: Using a 30~33 gauge needle, administer 0.1ml(4U) each on 3 areas on one of the outer regions of the orbicularis oculi muscles (6 areas on both sides, total of 24 U).

To treat blepharospasm: Blepharospasm is defined as the uncontrollable muscle movements of the eyelid. Coretox 100 Units should be administered using a sterile, 27-30 gauge needle, and injected into the medial and lateral pre-tarsal orbicularis oculi of the upper lid and into the lateral pre-tarsal orbicularis oculi of the lower lid. The initial recommended dose is 1.25-2.5U, at 0.05 mL to 0.1 mL volume at each site. The initial effect of Coretox 100 Units is generally seen 3 days after being injected. Full effects are seen 1 to 2 weeks after injection. The effects last approximately 3 months. If the initial treatment is deemed insufficient (i.e. effects do not last longer than 2 months), then the dose can be increased up to two-fold in repeat treatment sessions. However, there seems to be little benefit from injecting more than 5.0 U per injection site. Patients may develop a tolerance if treatments for blepharospasm are administered more frequently than every three months. The cumulative dose of Coretox 100 Units should not exceed 200 U in a 30-day period.

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‌To address the masseter(jaw) muscle: Before getting the injections, it is important to have a consultation with a medical professional that will examine the jaw and face area to determine the injection site. A medical professional will clean the skin before the injection to reduce the risk of infection. A topical anesthesia to numb the area may be used. Next, the doctor will insert the thin needle into the masseter muscle. After the procedure is completed and the toxin is injected, the needle will be slowly withdrawn. The procedure may be repeated on the other side of the face.It is important to AVOID rubbing and placing pressure on the treated area for 24 hours.

To treat neck wrinkles: During the injection into the neck area, it is important to contract and relax the platysma muscle multiple times, in order to let the doctor evaluate and select the right area that needs the injections. With the contraction of the muscle, the lines are more visible, and the doctor can grab the muscle and inject botulinum toxin into it. As botulinum toxin weakens the muscles, the motion of the platysma muscle becomes very limited, thanks to that the neck looks smoother by softening the wrinkles and lines. Moreover, as there are no involuntary contractions, the neck appears tighter as well, indirectly improving the appearance of jowls and jawline too.

To administer as skin botox: Skin botox is created by mixing 4 to 5 times more saline solution than the traditional dilution ratio for botulinum toxin procedures. This dilutes the toxin more thinly. The diluted solution should be administered into the dermal layer (skin), which is different from the traditional technique, which administers the toxin solution into the muscle. Skin botox should be injected in small amounts in several small increments in facial areas. Effects of skin botox include the tightening of pores, the reduction of fine lines, the reduced production of oil and sweat, and the overall smoother appearance of skin.

Precautions when using Coretox 100 Units
Coretox 100 Units should be discarded as medical waste once it has passed the expiration date. If the toxin needs to be deactivated (e.g. when spilled out), use diluted hypochlorite(0.5% or 1%) before discarding it as medical waste. Also, products that have come in direct contact with Meditoxin 100 U should also be discarded as medical waste.

Coretox 100 Units is not recommended to be injected frequently. Frequency should not exceed one treatment every 3 months.

The recommended dosage, frequency of treatment, and administration methods of Coretox 100 Units should be strictly followed. Certified professionals administering Coretox 100 Units should fully understand the relevant neuromuscular and/or orbital anatomy of the treatment area, and also any alterations to the anatomy that have occurred due to prior surgical procedures. DO NOT use Coretox 100 Units without a doctor’s prescription.

The following people SHOULD NOT receive Coretox 100 Units:

- Patients who have an allergic or hypersensitive reaction to the ingredients in this product

- Patients with neuromuscular junction disorders (dysfunction at location where nerves connect with muscles), including Myasthenia gravis, Lambert-Eaton syndrome, Amyotrophic lateral sclerosis. Using this product causes relaxation of the muscle, which can exacerbate the existing disorder.

- Patients who are pregnant, planning to get pregnant, or are currently nursing mothers

- Patients below the age of 16

Why is Coretox 100 Units recommended?

Coretox 100 Unit is recommended to clients who want an effective, safe, high-quality Korean toxin product manufactured by one of the top South Korean biopharmaceutical companies in the industry, MedyTox. Furthermore, Coretox 100 Unit is highly recommended for all those clients that want to improve their glabellar wrinkles with a safe and highly effective treatment. In addition, as Coretox 100 Unit does not have any animal component, the risk of potential infection by blood-derived pathogens or infectious microorganisms is extremely low.

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※ Caution
We, Medi-Fella Korea, do NOT take any responsibility for medical issues and problems that occur during cosmetic procedures.